Stereoselectivity technique for chiral compounds

The present disclosure provides, among other aspects, techniques for the stereoselective preparation of chiral compounds. In some embodiments, the prepared chiral compounds can be used for chirally controlled preparation of oligonucleotides. In some embodiments, such oligonucleotide target transcripts are associated with various conditions, disorders, or diseases. 除了其他方面，本披露提供了用于立体选择性制备手性化合物的技术。在一些实施例中，所制备的手性化合物可用于寡核苷酸的手性控制制备。在一些实施例中，这样的寡核苷酸靶标转录物与各种病症、障碍或疾病相关。