Preparation method of 2 '-hexadecyloxy guanosine derivative

The invention discloses a preparation method of a 2 '-hexadecyloxy guanosine derivative, and belongs to the technical field of synthesis of medical intermediates. 6-chloridine is used as a starting material, the 6 # site is subjected to methoxyl substitution, hydroxyl at the 2' site is subjected to hexadecylation, the methoxyl at the 6 # site is oxidized into carbonyl, amino at the 2 # site is protected by isobutyryl, and 4, 4 '-hexadecyloxy guanosine derivative is obtained by reacting 4, 4'-hexadecyloxy guanosine with 4, 4 '-hexadecyloxy guanosine at the 4, 4'-hexadecyloxy guanosine at the 4, 4 '-hexadecyloxy guanosine. The method for selectively introducing the long aliphatic chain to the 2 '-position of the guanosine overcomes the defects that in the prior art, the reaction time is slow, the conversion rate is low and amplified production is not facilitated, and the method for selectively introducing the long aliphatic chain to the 2'-position of the guanosine is provided. 本发明公开了一种2'十六烷氧基鸟苷衍生物的制备方法，属于医药中间体