Isoxazoline compound as well as preparation and application thereof

The invention relates to the technical field of chemical pharmacy, in particular to an isoxazoline compound as well as preparation and application thereof. The preparation method comprises the following steps: firstly, dissolving 2-methyl-4-formaldoxime methyl benzoate, then carrying out chlorination reaction on the dissolved 2-methyl-4-formaldoxime methyl benzoate and N-chlorosuccinimide, then transferring to room temperature, adding 1, 3-dichloro-5-(1-trifluoromethyl-vinyl) benzene, and carrying out cyclization reaction to obtain a first intermediate; dissolving sodium hydroxide and the first intermediate, and reacting to obtain a second intermediate; dissolving the second intermediate and thionyl chloride, uniformly mixing, dropwise adding N, N-dimethylformamide, and reacting to obtain a third intermediate; finally, dissolving the third intermediate, dropwise adding the third intermediate into the first solution to carry out a first reaction, then adding a lithium hydroxide solution, and carrying out a sec