Preparation method of injectable dextran/polycaprolactone/poly-L-lactic acid ternary interpenetrating network microsphere composite dextran hydrogel filler

The invention discloses a preparation method of an injectable dextran/poly-L-lactic acid interpenetrating network microsphere composite hydrogel filler. The preparation method comprises the following preparation steps: (1) synthesizing a polymerizable poly-L-lactic acid-dextran copolymer; (2) prepar...

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Bibliographische Detailangaben
Hauptverfasser: FU RONGQIANG, NIE JINGJING, ZHU SHAOXIONG, DU BINYANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of an injectable dextran/poly-L-lactic acid interpenetrating network microsphere composite hydrogel filler. The preparation method comprises the following preparation steps: (1) synthesizing a polymerizable poly-L-lactic acid-dextran copolymer; (2) preparation of polymerizable dextran; (3) preparation of poly (L-lactic acid)-dextran interpenetrating network microspheres; (4) preparing the dextran microspheres; and (5) preparing the injectable poly (L-lactic acid)-dextran interpenetrating network microsphere and dextran microsphere composite hydrogel filling agent. The preparation method disclosed by the invention has the following beneficial effects that the treatment condition is mild, the preparation method is suitable for large-scale production, and the obtained injectable poly-L-lactic acid-dextran interpenetrating network microsphere and dextran microsphere composite hydrogel filling agent has good biocompatibility and degradability and is suitable for the fie