Application of ZFP36L2 gene in treatment and/or prevention of radiation damage
The invention belongs to the field of biomedicine, and particularly relates to application of a ZFP36L2 gene in treatment and/or prevention of radiation damage. The application is the application of ZFP36L2 in the following (A1) or (A2) or (A3): (A1) preparing a medicine for treating and/or preventi...
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| creator | WU QI ZHANG CHENGWEI HE JINCHEN WANG YUYUAN WU TIANQI SHU YUJIA |
| description | The invention belongs to the field of biomedicine, and particularly relates to application of a ZFP36L2 gene in treatment and/or prevention of radiation damage. The application is the application of ZFP36L2 in the following (A1) or (A2) or (A3): (A1) preparing a medicine for treating and/or preventing radiation damage; (A2) preparing a medicine for resisting mitochondrial dysfunction caused by radiation; and (A3) preparing a medicine for treating the vascular endothelial injury caused by radiation. Experiments prove that mitochondrial dysfunction caused by radiation can be resisted by adjusting the expression level of the ZFP36L2 in the macrophages, and in-vitro experiments verify that the scratch healing ability of the HUVEC under the irradiation condition is remarkably improved by the macrophage supernate overexpressed by the ZFP36L2; further experiments prove that the ZFP36L2 overexpressed macrophage can remarkably relieve damage to abdominal cavity tissue of transplanted mice in a radiation environment an |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE |
| title | Application of ZFP36L2 gene in treatment and/or prevention of radiation damage |
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