Preparation method of multivalent anti-cobra venom horse plasma antibody

The invention relates to a preparation method of a multivalent anti-cobra venom horse plasma antibody. The preparation method comprises the following steps: 1) selecting and collecting snake venom; 2) detoxification treatment of snake venom; (3) preparing a snake venom antigen; and 4) preparing the...

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Bibliographische Detailangaben
Hauptverfasser: WANG LEI, LI QIYI, FAN QUANSHUI, ZHENG YING, YANG TINGCHAN, WU YANHUA, TU KEYAO, CHEN YIMIN, ZHU KANGHUA, JIAO ZEWU, WU HUIYAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a preparation method of a multivalent anti-cobra venom horse plasma antibody. The preparation method comprises the following steps: 1) selecting and collecting snake venom; 2) detoxification treatment of snake venom; (3) preparing a snake venom antigen; and 4) preparing the multivalent anti-cobra venom horse plasma antibody. According to the method, the cobra venom is treated differently from the bungarus multicinctus venom and the krait venom, so that the goals of retaining the immunogenicity of the cobra venom as far as possible and reducing the toxicity of the bungarus multicinctus venom and the krait venom are achieved; a single-point low-toxicity and multi-point distribution method is adopted, so that the toxic damage of immunogen of horses can be reduced, and continuous stimulation and synergism are realized; the qualified success rate of the anti-bungarus multicinctus poison titer, the anti-cobra poison titer and the anti-krait poison titer of the horse prepared by the method d