Antibacterial hydrogel nanoparticles as well as preparation method and application thereof

The invention relates to the technical field of antibacterial drug preparation, in particular to antibacterial hydrogel based on multiple chemotherapeutic agents and a preparation method and application of the antibacterial hydrogel. The preparation method of the antibacterial hydrogel nanoparticles comprises the following steps: preparing a hydrogel solution containing colistin, then adding CHE liposome, mixing, and rapidly cooling to room temperature to obtain the antibacterial hydrogel nanoparticles, and the melting point T1 of the hydrogel is more than or equal to 45 DEG C and less than or equal to 55 DEG C. The antibacterial hydrogel nano-particles simultaneously encapsulate CHE and colistin, can resist bacteria synergistically, and is used for resisting persistent bacteria in an ESKAPE pathogen group. 本发明涉及抗菌药物制备技术领域，具体涉及一种基于多种化学治疗剂的抗菌水凝胶及其制备方法和应用。该抗菌水凝胶纳米颗粒的制备方法，包括步骤，配置含有粘菌素的水凝胶溶液，然后加入CHE脂质体，混合、快速冷却至室温得到所述的抗菌水凝胶纳米颗粒，所述水凝胶的熔点T1满足：45℃≤T1≤55℃。本发明的抗菌水凝胶纳米颗粒同时封装了CHE和粘菌素，可协同抗菌，用于对抗ESKAPE病原体组中的持久性细菌。