Bispecific CD16A binding agents

The present invention relates to a bispecific antibody construct comprising (a) a first binding domain (A) capable of specifically binding to a first target (A ') which is CD16A on the surface of an immune effector cell wherein the first binding domain comprises: (i) a VL region comprising CDR-L1 as shown in SEQ ID NO: 4, CDR-L2 as shown in SEQ ID NO: 5 and CDR-L3 as shown in SEQ ID NO: 6, and (ii) a VH region as shown in SEQ ID NO: 7; and (b) a second binding domain (B) capable of specifically binding to a second target (B '), said second target (B') being an antigen on the surface of a target cell wherein said second target (B ') is FOLR1. The invention also relates to related nucleic acid molecules, vectors, host cells, methods of producing antibody constructs, pharmaceutical compositions, medical uses and kits. 本发明涉及一种双特异性抗体构建体，其包含(a)第一结合结构域(A)，其能够特异性结合第一靶标(A')，所述第一靶标(A')是免疫效应细胞表面上的CD16A，其中所述第一结合结构域包含：(i)包含如SEQ ID NO:4所示的CDR-L1、如SEQ ID NO:5所示的CDR-L2和如SEQ ID NO:6所示的CDR-L3的VL区，和(ii)如SEQ ID NO:7所示的VH区；以及(b)第