Fusion protein capable of promoting secretion of cell membrane fixed protein, recombinant vaccine and application
The invention relates to a vaccine framework fusion protein, a recombinant vaccine, application of the vaccine framework fusion protein and the recombinant vaccine and the like. The fusion proteins of the invention comprise an intracellular fragment of a low affinity immunoglobulin gamma Fc region r...
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| creator | LI JING XU SHI HAN TIYUN |
| description | The invention relates to a vaccine framework fusion protein, a recombinant vaccine, application of the vaccine framework fusion protein and the recombinant vaccine and the like. The fusion proteins of the invention comprise an intracellular fragment of a low affinity immunoglobulin gamma Fc region receptor II (Fc gamma RII) and a WW domain (WW domain) of an E3 ubiquitin protein ligase Nedd4 family member protein, and/or one or more antigens, and/or one or more transmembrane regions. The invention provides a brand-new recombinant vaccine molecular architecture which has a better capability of promoting expression and secretion of immune antigens and an effect of improving the immune level, provides a new thought and a new method for a design scheme of recombinant vaccines, and can be widely applied to the field of vaccines.
本发明涉及一种疫苗架构融合蛋白、重组疫苗及其应用等。本发明的融合蛋白包含低亲和力免疫球蛋白γFc区受体II（FcγRII）的胞内段和E3泛素蛋白连接酶Nedd4家族成员蛋白的WW结构域（WW domain），和/或一种或多种抗原，和/或一种或多种跨膜区。本发明提供了一种全新的重组疫苗分子架构，具备更优的促进免疫抗原表达、分泌的能力，提高免疫水平的效果，为重组疫苗的设计方案提供 |
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本发明涉及一种疫苗架构融合蛋白、重组疫苗及其应用等。本发明的融合蛋白包含低亲和力免疫球蛋白γFc区受体II（FcγRII）的胞内段和E3泛素蛋白连接酶Nedd4家族成员蛋白的WW结构域（WW domain），和/或一种或多种抗原，和/或一种或多种跨膜区。本发明提供了一种全新的重组疫苗分子架构，具备更优的促进免疫抗原表达、分泌的能力，提高免疫水平的效果，为重组疫苗的设计方案提供</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240910&DB=EPODOC&CC=CN&NR=118620085A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240910&DB=EPODOC&CC=CN&NR=118620085A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LI JING</creatorcontrib><creatorcontrib>XU SHI</creatorcontrib><creatorcontrib>HAN TIYUN</creatorcontrib><title>Fusion protein capable of promoting secretion of cell membrane fixed protein, recombinant vaccine and application</title><description>The invention relates to a vaccine framework fusion protein, a recombinant vaccine, application of the vaccine framework fusion protein and the recombinant vaccine and the like. The fusion proteins of the invention comprise an intracellular fragment of a low affinity immunoglobulin gamma Fc region receptor II (Fc gamma RII) and a WW domain (WW domain) of an E3 ubiquitin protein ligase Nedd4 family member protein, and/or one or more antigens, and/or one or more transmembrane regions. The invention provides a brand-new recombinant vaccine molecular architecture which has a better capability of promoting expression and secretion of immune antigens and an effect of improving the immune level, provides a new thought and a new method for a design scheme of recombinant vaccines, and can be widely applied to the field of vaccines.
本发明涉及一种疫苗架构融合蛋白、重组疫苗及其应用等。本发明的融合蛋白包含低亲和力免疫球蛋白γFc区受体II（FcγRII）的胞内段和E3泛素蛋白连接酶Nedd4家族成员蛋白的WW结构域（WW domain），和/或一种或多种抗原，和/或一种或多种跨膜区。本发明提供了一种全新的重组疫苗分子架构，具备更优的促进免疫抗原表达、分泌的能力，提高免疫水平的效果，为重组疫苗的设计方案提供</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDELwjAQRrs4iPofzl2hVZSuUixOTu7ler3KQXKJSRR_vg3o7vTB471vXjzaZxSn4INLLAqEHnvD4MaMrEuid4hMgVPWJkxsDFi2fUBlGOXNw6_eQGBythdFTfBCIpkU1AHQeyOE-WNZzEY0kVffXRTr9nxrLlv2ruPokVg5dc21qurjrizrw2n_j_MByzhD_g</recordid><startdate>20240910</startdate><enddate>20240910</enddate><creator>LI JING</creator><creator>XU SHI</creator><creator>HAN TIYUN</creator><scope>EVB</scope></search><sort><creationdate>20240910</creationdate><title>Fusion protein capable of promoting secretion of cell membrane fixed protein, recombinant vaccine and application</title><author>LI JING ; XU SHI ; HAN TIYUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118620085A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LI JING</creatorcontrib><creatorcontrib>XU SHI</creatorcontrib><creatorcontrib>HAN TIYUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LI JING</au><au>XU SHI</au><au>HAN TIYUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Fusion protein capable of promoting secretion of cell membrane fixed protein, recombinant vaccine and application</title><date>2024-09-10</date><risdate>2024</risdate><abstract>The invention relates to a vaccine framework fusion protein, a recombinant vaccine, application of the vaccine framework fusion protein and the recombinant vaccine and the like. The fusion proteins of the invention comprise an intracellular fragment of a low affinity immunoglobulin gamma Fc region receptor II (Fc gamma RII) and a WW domain (WW domain) of an E3 ubiquitin protein ligase Nedd4 family member protein, and/or one or more antigens, and/or one or more transmembrane regions. The invention provides a brand-new recombinant vaccine molecular architecture which has a better capability of promoting expression and secretion of immune antigens and an effect of improving the immune level, provides a new thought and a new method for a design scheme of recombinant vaccines, and can be widely applied to the field of vaccines.
本发明涉及一种疫苗架构融合蛋白、重组疫苗及其应用等。本发明的融合蛋白包含低亲和力免疫球蛋白γFc区受体II（FcγRII）的胞内段和E3泛素蛋白连接酶Nedd4家族成员蛋白的WW结构域（WW domain），和/或一种或多种抗原，和/或一种或多种跨膜区。本发明提供了一种全新的重组疫苗分子架构，具备更优的促进免疫抗原表达、分泌的能力，提高免疫水平的效果，为重组疫苗的设计方案提供</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Fusion protein capable of promoting secretion of cell membrane fixed protein, recombinant vaccine and application |
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