Fusion protein capable of promoting secretion of cell membrane fixed protein, recombinant vaccine and application

The invention relates to a vaccine framework fusion protein, a recombinant vaccine, application of the vaccine framework fusion protein and the recombinant vaccine and the like. The fusion proteins of the invention comprise an intracellular fragment of a low affinity immunoglobulin gamma Fc region receptor II (Fc gamma RII) and a WW domain (WW domain) of an E3 ubiquitin protein ligase Nedd4 family member protein, and/or one or more antigens, and/or one or more transmembrane regions. The invention provides a brand-new recombinant vaccine molecular architecture which has a better capability of promoting expression and secretion of immune antigens and an effect of improving the immune level, provides a new thought and a new method for a design scheme of recombinant vaccines, and can be widely applied to the field of vaccines. 本发明涉及一种疫苗架构融合蛋白、重组疫苗及其应用等。本发明的融合蛋白包含低亲和力免疫球蛋白γFc区受体II（FcγRII）的胞内段和E3泛素蛋白连接酶Nedd4家族成员蛋白的WW结构域（WW domain），和/或一种或多种抗原，和/或一种或多种跨膜区。本发明提供了一种全新的重组疫苗分子架构，具备更优的促进免疫抗原表达、分泌的能力，提高免疫水平的效果，为重组疫苗的设计方案提供