Salt form and polymorphic form of allopregnanolone derivative as well as preparation method and application of salt form and polymorphic form

The invention provides various salt forms of an allopregnanolone derivative. The various salt forms comprise hydrochloride, phosphate, L-malate, maleate, p-toluenesulfonate, benzoate and the like. The invention also provides a plurality of crystal forms and amorphous forms of the allopregnanolone derivative hydrochloride, including a crystal form I, a crystal form II, a crystal form III and a crystal form IV. Hydrochloride and phosphate of the allopregnanolone derivative have good stability, and the preparation method is simple and easy to operate, is suitable for large-scale production and has good industrial application value. # imgabs0 # 本发明提供了别孕烷醇酮衍生物的多种盐型，包括盐酸盐、磷酸盐、L-苹果酸盐、马来酸盐、对甲苯磺酸盐和苯甲酸盐等；本发明还提供了别孕烷醇酮衍生物盐酸盐的多种晶型及无定形形式，包括晶型Ⅰ、晶型Ⅱ、晶型Ⅲ和晶型Ⅳ。其中，别孕烷醇酮衍生物的盐酸盐和磷酸盐均具有良好的稳定性，且制备方法简单易操作，适于放大生产，具有良好的工业化应用价值。#imgabs0#