Suspension and preparation method thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a suspension and a preparation method thereof. The suspension provided by the invention is free of gravel feeling, easy to swallow and convenient for a patient to use, and the suspension process...

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Bibliographische Detailangaben
Hauptverfasser: QIU XIAOFENG, CAI ZHOURU, YU XIHUA, ZHANG JUAN, YANG LINYING, ZHONG XIAOQIN, ZHENG PEIJUAN, XU FUCHUN, CHEN XISHENG, SHI ZHENXIANG, CHEN WEIQIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a suspension and a preparation method thereof. The suspension provided by the invention is free of gravel feeling, easy to swallow and convenient for a patient to use, and the suspension process adopts repeated homogenization for multiple times, so that the phenomena of sedimentation, flocculation and layering are avoided in the long-time placement process. The suspension is prepared from 20%-40% (w/w) of natural clay, 0.01%-0.1% of a sweetening agent, 0.05%-0.25% of sodium benzoate, 0.05%-0.25% of potassium sorbate, 1.6%-2.4% of edible essence and a proper amount of a pH regulator and purified water. 本发明属于药物制剂技术领域,具体涉及一种混悬剂及其制备方法。本发明提供了一种无砂砾感、容易吞咽、方便患者使用的混悬剂,该混悬剂工艺采用多次反复均质,从而保证长时间放置过程中未发生沉降、凝絮、分层现象。本发明混悬剂包括天然黏土20~40%(w/w)、甜味剂0.01~0.1%、苯甲酸钠0.05~0.25%、山梨酸钾0.05~0.25%、可食用香精1.6~2.4%,以及适量pH调节剂和纯化水。