Cyclic 2-amino-3-cyanothiophenes and derivatives for treatment of cancer

The invention encompasses compounds of formula (I) # imgabs0 # wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and the description; the use of said compounds as inhibitors of mutant Ras family proteins; pharmaceutical compositions and formulations containing such compounds; and to the use of said pharmaceutical compositions and formulations as medicaments/medical, in particular as agents for the treatment and/or prophylaxis of carcinogenic diseases. 本发明涵盖式(I)化合物#imgabs0#其中R1a、R1b、R2a、R2b、Z、R3至R5、A、p、L、U、V及W具有权利要求书及说明书中所给出的含义；所述化合物作为突变体Ras家族蛋白质的抑制剂的用途；含有此类化合物的药物组合物及制剂；及所述药物组合物及制剂作为药剂/医疗用途，尤其作为用于治疗和/或预防致癌性疾病的试剂的用途。