Application of reagent for detecting anti-FARP1 autoantibody in preparation of product for detecting autoimmune diseases of nervous system

The invention belongs to the technical field of biological medicines, and particularly relates to application of a reagent for detecting an anti-FARP1 autoantibody to preparation of a product for detecting autoimmune diseases of a nervous system. The serum of a patient with nervous system diseases a...

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Hauptverfasser: WANG YU, REN NI, YAN YAPING, YANG ZI, ZHANG ZHEWEI, LIU RUIMAN, WANG YALAN, CHAI SHANSHAN, XI QIAN, LIU HUI, FAN XUE, LI KE, GUO JUN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of biological medicines, and particularly relates to application of a reagent for detecting an anti-FARP1 autoantibody to preparation of a product for detecting autoimmune diseases of a nervous system. The serum of a patient with nervous system diseases and the serum of a healthy person are used as experimental materials, rat brain tissue slices are incubated respectively, signals are amplified through a fluorescent secondary antibody, and compared with the serum of the healthy person, the autoantibody FARP1 exists in the serum of the patient with nervous system autoimmune diseases in a manner of co-dyeing with a neuron specific Marker antibody; the invention also verifies the authenticity and the specificity of the target antigen, and indicates that the FARP1 protein is expressed in mouse brain tissues and rat neurons and has an obvious dyeing signal, and the FARP1 can be used as one of recognition antigens of autoantibodies related to the nervous system autoimmun