Fluorescent probe for polarity detection of lipid droplets as well as preparation method and application of fluorescent probe

The invention provides a fluorescent probe for lipid droplet polarity detection and a preparation method and application thereof.The structural formula of the fluorescent probe is shown in the specification, the sensitivity to polarity change is high, and when the polarity parameter delta f ranges from 0.16 to 0.3, the fluorescence intensity and the polarity change have a good linear relation; the fluorescent probe CHBT-B has the advantages of good selectivity, strong lipid droplet targeting, small phototoxicity and the like, has large Stokes shift and red light emission wavelength, and is suitable for detecting the polarity change of biological lipid droplets. # imgabs0 # 本发明提供一种用于脂滴极性检测的荧光探针及其制备方法和应用，其中，荧光探针的结构式如下所示，对极性变化灵敏度高，且在极性参数Δf＝0.16-0.3间荧光强度与极性变化有较好的线性关系；荧光探针CHBT-B具有选择性好，脂滴靶向性强、光毒性小等优点，具有较大的斯托克斯位移和红光发射波长，适合用于生物脂滴极性变化检测。#imgabs0#