Microwave synthesis method of cycloxaprid

The invention provides a microwave synthesis method of cycloxaprid, which comprises the following steps: adding a solvent, 2-chloro-5-((2-(nitromethylene) imidazoline-1-yl) methyl) pyridine, 2, 5-dichlorotetrahydrofuran and an acid-binding agent into a reactor, and condensing under a microwave react...

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Hauptverfasser: XU HAIYAN, BAI QING, WANG TAO, KONG QIANGUANG, BI QIANG, ZHANG YUAN, LI ZHONG, YU JINGJING, HAN HAIPING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a microwave synthesis method of cycloxaprid, which comprises the following steps: adding a solvent, 2-chloro-5-((2-(nitromethylene) imidazoline-1-yl) methyl) pyridine, 2, 5-dichlorotetrahydrofuran and an acid-binding agent into a reactor, and condensing under a microwave reaction condition to obtain the cycloxaprid. According to the microwave synthesis method of cycloxaprid, microwave catalysis is adopted, alkali serves as an acid-binding agent, 2-chloro-5-((2-(nitromethylene) imidazoline-1-yl) methyl) pyridine and 2, 5-dichlorotetrahydrofuran are subjected to condensation to obtain cycloxaprid, compared with a traditional process, the raw material cost is low, the reaction time is shorter, the reaction efficiency is greatly improved, the yield is higher, and the method is suitable for industrial production. The synthesis process is simple in post-treatment, salt is directly filtered out, cycloxaprid is obtained through cooling crystallization, and the method is suitable for large-scale