Targeted inhibitor, application and medicine for treating cancer

The invention belongs to the technical field of design and synthesis of drugs, and particularly relates to a targeted inhibitor, application and a drug for treating cancers. The invention develops and synthesizes a series of compounds (EPII-1-15), and discovers a part of compounds with excellent inhibition effects from the series of compounds. Wherein the compound EPI-15 has inhibitory activity on a human colon cancer cell COLO-205, a human melanoma cell A375, a human skin cancer cell A2058 and a human colon cancer cell HT-29. Besides, the invention also explores a synthesis path of the series of compounds and intermediates thereof, realizes efficient synthesis of the series of compounds and intermediates thereof, and provides a synthesis thought and method with reference value for subsequent drug research and development. 本发明属于药物的设计与合成技术领域，具体涉及一种靶向抑制剂、用途及治疗癌症的药物。本发明开发合成了系列化合物（EPII-1~15），并且从中发现了部分具有优良抑制效果的化合物。其中，化合物EPII-15对人结肠癌细胞COLO-205、人黑色素瘤细胞A375、人皮肤癌细胞A2058和人结肠癌细胞HT-29均具有抑制活性。此外，本发明还探索了系列化合物及其中间体的合成路径，并实现