Diphenyltriazine compound as well as preparation method and application thereof

The invention belongs to the technical field of chemical medicines, and particularly relates to a diphenyl triazine compound as well as a preparation method and application thereof. The diphenyl triazine compound does not have a PGI2 skeleton, has very strong selectivity and affinity to a PGI2 receptor, and has good target spot selectivity compared with a PGI2 analogue. Experiments prove that the in-vivo efficacy of the compound is superior to that of selexipag, and the toxicity of the compound is far lower than that of the selexipag, so that the compound can be used as a pulmonary arterial hypertension treatment medicine with higher clinical value and development prospect. 本发明属于化学药技术领域，具体涉及一种二苯基三嗪类化合物及其制备方法和应用。该二苯基三嗪类化合物不具有PGI2骨架，对PGI2受体有很强的选择性和亲和性，与PGI2类似物相比，具有良好的靶点选择性。经实验验证，该化合物体内药效优于司来帕格，且其毒性远远小于司来帕格，因此，该化合物可作为一种更有临床价值和开发前景的肺动脉高压治疗药物。