SiRNA and mRNA combined vaccine for treating HBV infection

The invention provides a siRNA and mRNA combined vaccine for treating HBV infection, and belongs to the technical field of medical preparations. The siRNA and mRNA combined vaccine comprises a siRNA vaccine and an mRNA vaccine; in the mRNA vaccine, the nucleotide sequence of mRNA is shown as SEQ ID NO: 3 in a sequence table. The siRNA and mRNA combined vaccine is used for treating hepatitis B virus, the siRNA vaccine can inhibit expression of the HBV virus, and the mRNA vaccine can induce immune response of an organism. The mRNA sequence in the mRNA vaccine is optimized, and the immune effect of the combined vaccine can be improved. In a mouse in-vivo pharmacodynamic experiment, compared with a combined vaccine of siRNA-LNP and control mRNA-LNP, the combined vaccine of the siRNA-LNP and the mRNA-LNP has a better immune effect by using the combined vaccine of the siRNA-LNP and the mRNA-LNP. 本发明提供一种用于治疗HBV感染的siRNA和mRNA联合疫苗，属于医用配制品技术领域。所述siRNA和mRNA联合疫苗包括siRNA疫苗和mRNA疫苗；所述mRNA疫苗中，mRNA的核苷酸序列如序列表中SEQ ID NO:3所示。本发明所述