KRAS degrading compounds comprising cyclic 2-amino-3-cyanothiophenes

The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be used as agents for the treatment and/or prophylaxis of neoplastic diseases. # imgabs0 # 本发明涉及式(I)的化合物和衍生物，所述化合物和衍生物靶向KRAS并可以用作用于治疗和/或预防肿瘤疾病的药剂。#imgabs0#...

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Hauptverfasser:	GOLLNER ANDREAS, TRAINOR NATHAN, MCCLONNAN REX, GOODWIN-TINDALL JAKE, WEINSTABLE HANNA, FARNABY WILLIAM, WATSON ANDREW, SOLLMANN DANIEL, CUI JIANWEN, HODGES TIM, DILS ERIC, FISIK SCOTT W, MANTOULIDIS, APOSTOLOS, SMUTHURST CORNELIS ADRIANUS PETRUS, ZHONG SHAN, EBT, J ¨ 1 RGEN, SARKAR DEEPAK, CIULLI, ALESSANDRO, KOFINK CHRISTIANE, LITTLE ALEX, POPOV, JULIA, BROEKER JOACHIM, SCHMIEDER MATTHIAS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be used as agents for the treatment and/or prophylaxis of neoplastic diseases. # imgabs0 # 本发明涉及式(I)的化合物和衍生物，所述化合物和衍生物靶向KRAS并可以用作用于治疗和/或预防肿瘤疾病的药剂。#imgabs0#