Linear lipopeptide compound with anti-tumor activity as well as preparation method and application thereof

Linear lipopeptide compound with anti-tumor activity as well as preparation method and application thereof

The invention discloses a linear lipopeptide compound with antineoplastic activity, the structure of the linear lipopeptide compound is as shown in # imgabs0, and the linear lipopeptide compound HJJS prepared by the invention shows an obvious proliferation inhibition effect under 11 tumor cell proli...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WANG DUHAO, YE CHEN, XU YAO, NING YAODONG, JIAO BINGHUA, QU YUJUN, LU ZHANYING, JIANG WENLI, LU XIAOLING
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention discloses a linear lipopeptide compound with antineoplastic activity, the structure of the linear lipopeptide compound is as shown in # imgabs0, and the linear lipopeptide compound HJJS prepared by the invention shows an obvious proliferation inhibition effect under 11 tumor cell proliferation models, and can be used for preparing antineoplastic drugs. 本发明公开了一种具有抗肿瘤活性的线性脂肽类化合物，结构如下所示：#imgabs0#本发明制备的线性脂肽类化合物HJJS在11种肿瘤细胞增殖模型下，均表现出显著的增殖抑制作用，可用于抗肿瘤药物的制备。