Double-layer composite bionic periosteum stent material with efficient blood vessel formation-osteogenesis promoting function and preparation method of double-layer composite bionic periosteum stent material

The invention discloses a double-layer composite bionic periosteum stent material with a function of efficiently promoting blood vessel formation and osteogenesis and a preparation method of the double-layer composite bionic periosteum stent material. The preparation method comprises the following s...

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Hauptverfasser:	JIN XIAOQIANG, YU ZHIJUN, LEI JIANGCHU, CHEN JIAYU, TENG-WANG SIYUAN, DAI CHENGXIN, YE ZHAOMING, YAN YU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
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creator	JIN XIAOQIANG YU ZHIJUN LEI JIANGCHU CHEN JIAYU TENG-WANG SIYUAN DAI CHENGXIN YE ZHAOMING YAN YU
description	The invention discloses a double-layer composite bionic periosteum stent material with a function of efficiently promoting blood vessel formation and osteogenesis and a preparation method of the double-layer composite bionic periosteum stent material. The preparation method comprises the following steps: (1) preparing the core-shell double-layer drug-loading microspheres loaded with the angiogenic differentiation drug by adopting a cross microfluidic technology; (2) preparing a polymer solution formed by mixing AlgMA and SilMA, uniformly mixing the drug-loaded microspheres with the polymer solution, pouring the mixture into a mold, and carrying out UV curing to obtain composite hydrogel; (3) carrying out a specific low-temperature oriented freezing process on the composite hydrogel to obtain an oriented porous composite scaffold with the pore diameter of 100-150 microns; (4) cutting the scaffold according to the shape of the allogeneic bone, and adhering the cut and sterilized scaffold to the surface of the a
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subjects	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
title	Double-layer composite bionic periosteum stent material with efficient blood vessel formation-osteogenesis promoting function and preparation method of double-layer composite bionic periosteum stent material
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