Double-layer composite bionic periosteum stent material with efficient blood vessel formation-osteogenesis promoting function and preparation method of double-layer composite bionic periosteum stent material

The invention discloses a double-layer composite bionic periosteum stent material with a function of efficiently promoting blood vessel formation and osteogenesis and a preparation method of the double-layer composite bionic periosteum stent material. The preparation method comprises the following steps: (1) preparing the core-shell double-layer drug-loading microspheres loaded with the angiogenic differentiation drug by adopting a cross microfluidic technology; (2) preparing a polymer solution formed by mixing AlgMA and SilMA, uniformly mixing the drug-loaded microspheres with the polymer solution, pouring the mixture into a mold, and carrying out UV curing to obtain composite hydrogel; (3) carrying out a specific low-temperature oriented freezing process on the composite hydrogel to obtain an oriented porous composite scaffold with the pore diameter of 100-150 microns; (4) cutting the scaffold according to the shape of the allogeneic bone, and adhering the cut and sterilized scaffold to the surface of the a