Preparation method of N-(2-(indole-1-yl) phenyl) benzenesulfonamide compound

The invention discloses a preparation method of an N-(2-(indole-1-yl) phenyl) benzenesulfonamide compound, which comprises the following steps: by taking N-phenylindole and a benzenesulfonyl azide compound as reaction raw materials, under a [RuCl2 (p-cymene)] 2 catalytic reaction system, adjusting r...

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Hauptverfasser:	LI JINHENG, LUO QUANJIAN, SUN BO, WANG HANCHI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	The invention discloses a preparation method of an N-(2-(indole-1-yl) phenyl) benzenesulfonamide compound, which comprises the following steps: by taking N-phenylindole and a benzenesulfonyl azide compound as reaction raw materials, under a [RuCl2 (p-cymene)] 2 catalytic reaction system, adjusting reaction parameters to obtain the N-(2-(indole-1-yl) phenyl) benzenesulfonamide compound. The N-(2-(indole-1-yl) phenyl) benzenesulfonamide compound serving as a CCR9 receptor inhibitor can be prepared with high selectivity and high yield. 本发明公开了一种N-(2-(吲哚-1基)苯基)苯磺酰胺类化合物的制备方法，该方法以N-苯基吲哚和苯磺酰叠氮类化合物为反应原料，在[RuCl2(p-cymene)]2催化反应体系下，通过调整反应参数，能够以高选择性、高收率地制备获得作为CCR9受体抑制剂的N-(2-(吲哚-1基)苯基)苯磺酰胺类化合物。