Synthetic method of 3-indolone

Synthetic method of 3-indolone

The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of 3-indolone. # imgabs0 is prepared by mixing an N-methylbenzylamine compound as shown in a formula 1 and a 2-fluorobenzoic acid methyl ester compound as shown in a formula 2 with an organic solv...

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Hauptverfasser: XIONG DAN, MA RUYUAN, FEI RONGBI, MAO JIANYOU, GU YUANYUN
Format: Patent
Sprache:chi ; eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator XIONG DAN
MA RUYUAN
FEI RONGBI
MAO JIANYOU
GU YUANYUN
description The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of 3-indolone. # imgabs0 is prepared by mixing an N-methylbenzylamine compound as shown in a formula 1 and a 2-fluorobenzoic acid methyl ester compound as shown in a formula 2 with an organic solvent (methyl tert-butyl ether) in the presence of a strong base (lithium bis (trimethylsilyl) amide) and a cesium salt additive (cesium fluoride), and reacting to synthesize 3-indolone as shown in a formula 3. The adopted raw materials are simple and easy to obtain, the method for synthesizing the 3-indolone through the one-pot method is constructed, and the method has the advantages of being simple in synthesis method, economical, environmentally friendly, wide in application range and the like. 本发明属于有机合成领域，特别涉及一种3-吲哚酮的合成方法。#imgabs0#采用式1所示N-甲基苄胺类化合物和式2所示2-氟苯甲酸甲酯类化合物在强碱(二(三甲基硅基)氨基锂)和铯盐添加剂(氟化铯)的存在下，与有机溶剂(甲基叔丁基醚)混合，反应合成式3所示3-吲哚酮。本发明所采用的原料简单易得，构建了一锅法合成3-吲哚酮的方法，具有合成方法简单、经济环保和适用范围广泛等优势。
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The adopted raw materials are simple and easy to obtain, the method for synthesizing the 3-indolone through the one-pot method is constructed, and the method has the advantages of being simple in synthesis method, economical, environmentally friendly, wide in application range and the like. 本发明属于有机合成领域，特别涉及一种3-吲哚酮的合成方法。#imgabs0#采用式1所示N-甲基苄胺类化合物和式2所示2-氟苯甲酸甲酯类化合物在强碱(二(三甲基硅基)氨基锂)和铯盐添加剂(氟化铯)的存在下，与有机溶剂(甲基叔丁基醚)混合，反应合成式3所示3-吲哚酮。本发明所采用的原料简单易得，构建了一锅法合成3-吲哚酮的方法，具有合成方法简单、经济环保和适用范围广泛等优势。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20240830&amp;DB=EPODOC&amp;CC=CN&amp;NR=118561738A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20240830&amp;DB=EPODOC&amp;CC=CN&amp;NR=118561738A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XIONG DAN</creatorcontrib><creatorcontrib>MA RUYUAN</creatorcontrib><creatorcontrib>FEI RONGBI</creatorcontrib><creatorcontrib>MAO JIANYOU</creatorcontrib><creatorcontrib>GU YUANYUN</creatorcontrib><title>Synthetic method of 3-indolone</title><description>The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of 3-indolone. # imgabs0 is prepared by mixing an N-methylbenzylamine compound as shown in a formula 1 and a 2-fluorobenzoic acid methyl ester compound as shown in a formula 2 with an organic solvent (methyl tert-butyl ether) in the presence of a strong base (lithium bis (trimethylsilyl) amide) and a cesium salt additive (cesium fluoride), and reacting to synthesize 3-indolone as shown in a formula 3. 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METALLURGY
ORGANIC CHEMISTRY
title Synthetic method of 3-indolone
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