Synthetic method of 3-indolone

The invention belongs to the field of organic synthesis, and particularly relates to a synthetic method of 3-indolone. # imgabs0 is prepared by mixing an N-methylbenzylamine compound as shown in a formula 1 and a 2-fluorobenzoic acid methyl ester compound as shown in a formula 2 with an organic solvent (methyl tert-butyl ether) in the presence of a strong base (lithium bis (trimethylsilyl) amide) and a cesium salt additive (cesium fluoride), and reacting to synthesize 3-indolone as shown in a formula 3. The adopted raw materials are simple and easy to obtain, the method for synthesizing the 3-indolone through the one-pot method is constructed, and the method has the advantages of being simple in synthesis method, economical, environmentally friendly, wide in application range and the like. 本发明属于有机合成领域，特别涉及一种3-吲哚酮的合成方法。#imgabs0#采用式1所示N-甲基苄胺类化合物和式2所示2-氟苯甲酸甲酯类化合物在强碱(二(三甲基硅基)氨基锂)和铯盐添加剂(氟化铯)的存在下，与有机溶剂(甲基叔丁基醚)混合，反应合成式3所示3-吲哚酮。本发明所采用的原料简单易得，构建了一锅法合成3-吲哚酮的方法，具有合成方法简单、经济环保和适用范围广泛等优势。