Improved method for preparing mildronate dihydrate and related salts thereof by buffer neutralization technology
The invention relates to an improved method for preparing mildronate dihydrate and related salts thereof by a buffer neutralization technology, mildronate is a medicine for cardiovascular diseases and is a product obtained by carrying out alkaline hydrolysis and acidification neutralization on an in...
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| Format: | Patent |
| Sprache: | chi ; eng |
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| Zusammenfassung: | The invention relates to an improved method for preparing mildronate dihydrate and related salts thereof by a buffer neutralization technology, mildronate is a medicine for cardiovascular diseases and is a product obtained by carrying out alkaline hydrolysis and acidification neutralization on an intermediate 3-(2, 2, 2-trimethylhydrazine) methyl propionate salt (CH3) 3N + NHCH2CH2COOCH3X-(wherein X represents Cl , Br , I and CH3SO4 ), and the mildronate is a product obtained by carrying out alkaline hydrolysis and acidification neutralization on the intermediate 3-(2, 2, 2-trimethylhydrazine) methyl propionate salt (CH3) 3N + NHCH2CH2COOCH3X-. According to the present invention, the known method for preparing the mildronate dihydrate and the mildronate salt is improved, the complex acidification purification separation process after hydrolysis is solved, the mildronate dihydrate or the mildronate salt is obtained by using the buffer neutralization technical method and the one-pot method, such th |
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