Conjugates of cell-binding molecules and camptothecin analogs

The invention relates to a conjugate of a camptothecin analogue with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and---are as defined in the specification. The invention also relates to methods of use of compositions containing the conjugates of camptothecin ana...

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Hauptverfasser:	XU YIFANG, ZHANG XIUZHEN, ZHANG LINGLI, ZHENG YUNXIA, KONG XIANGFEI, YE HANGBO, CHEN MIAOMIAO, CHEN DIANCHENG, ZHAO GENGXIANG, GUO HUIHUI, YANG QINGLIANG, HUANG SHANGMA, HUANG YUANYUAN, BAI LU, CHEN XIAOXIAO, YE RIPING, LI WENJUN, ZHENG JUN, JIA JUNXIANG, DU YONG, GUO ZHIXIANG, ZHAO RUI, JIANG XINGYAN, CAI XIANG, LI YANHUA, ZHENG WEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to a conjugate of a camptothecin analogue with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and---are as defined in the specification. The invention also relates to methods of use of compositions containing the conjugates of camptothecin analogs and cell-binding molecules in the treatment of cancer, autoimmune system diseases and infectious diseases. 本发明涉及一种喜树碱类似物与式(I)细胞结合分子的偶联物，其中R1,R2,R3,R4,R5,X,L,n,m,T和---如定义中所述。本发明还涉及含有喜树碱类似物与细胞结合分子偶联物的组合物在治疗癌症、自免疫系统疾病和感染性疾病上的应用方法。