Process for preparation of sartan active compounds having tetrazole ring

The present disclosure relates to a process for the manufacture of at least one sartan active compound of formula (I) wherein R is selected from the group consisting of formulae (1), (2), (3), (4) and (5), comprising the tetrazolation of a compound of formula (II) wherein R is as previously defined, in a reaction medium having at least one azide derivative, wherein a benzyl azide impurity formed during the tetrazolation is converted to an aldehyde derivative. # imgabs0 # 本公开文本涉及一种用于制造至少一种式(I)的沙坦活性化合物的方法其中R选自式(1)、(2)、(3)、(4)和(5)，所述方法包括一种式(II)的化合物在具有至少一种叠氮化物衍生物的反应介质中的四唑化，其中R是如先前所定义的，其中在所述四唑化期间形成的苄基叠氮化物杂质被转化为醛衍生物。#imgabs0#