Three-strand formation oligonucleotides for inhibiting expression of E26 transcription factor 2 and application of three-strand formation oligonucleotides
The invention relates to the technical field of biological medicine, in particular to three-strand forming oligonucleotides for inhibiting E26 transcription factor 2 gene expression and application of the three-strand forming oligonucleotides, and the three-strand forming oligonucleotides and a prom...
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| creator | WANG LEI WANG DEZHI LEI WENZHUO |
| description | The invention relates to the technical field of biological medicine, in particular to three-strand forming oligonucleotides for inhibiting E26 transcription factor 2 gene expression and application of the three-strand forming oligonucleotides, and the three-strand forming oligonucleotides and a promoter core region of an E26 transcription factor 2 gene can form an oligonucleotide sequence of three-strand DNA (Deoxyribose Nucleic Acid). A polyacrylamide gel electrophoresis experiment, an in-vitro transcription inhibition experiment and a cell proliferation inhibition experiment prove that the three-strand-forming oligonucleotide can form a stable three-strand DNA structure with a promoter core region, the transcriptional level of an E26 transcription factor 2 is inhibited, and the drug resistance of breast cancer cells to adriamycin is reduced. Meanwhile, the invention can be used for preparing drugs for treating breast cancer drug resistance.
本发明涉及生物医药技术领域，尤其涉及一类抑制E26转录因子2基因表达的三链形成寡核苷酸及其应用，该三链形成寡核苷酸能与E26转录因子2 |
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本发明涉及生物医药技术领域，尤其涉及一类抑制E26转录因子2基因表达的三链形成寡核苷酸及其应用，该三链形成寡核苷酸能与E26转录因子2</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240827&DB=EPODOC&CC=CN&NR=118546925A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240827&DB=EPODOC&CC=CN&NR=118546925A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG LEI</creatorcontrib><creatorcontrib>WANG DEZHI</creatorcontrib><creatorcontrib>LEI WENZHUO</creatorcontrib><title>Three-strand formation oligonucleotides for inhibiting expression of E26 transcription factor 2 and application of three-strand formation oligonucleotides</title><description>The invention relates to the technical field of biological medicine, in particular to three-strand forming oligonucleotides for inhibiting E26 transcription factor 2 gene expression and application of the three-strand forming oligonucleotides, and the three-strand forming oligonucleotides and a promoter core region of an E26 transcription factor 2 gene can form an oligonucleotide sequence of three-strand DNA (Deoxyribose Nucleic Acid). A polyacrylamide gel electrophoresis experiment, an in-vitro transcription inhibition experiment and a cell proliferation inhibition experiment prove that the three-strand-forming oligonucleotide can form a stable three-strand DNA structure with a promoter core region, the transcriptional level of an E26 transcription factor 2 is inhibited, and the drug resistance of breast cancer cells to adriamycin is reduced. Meanwhile, the invention can be used for preparing drugs for treating breast cancer drug resistance.
本发明涉及生物医药技术领域，尤其涉及一类抑制E26转录因子2基因表达的三链形成寡核苷酸及其应用，该三链形成寡核苷酸能与E26转录因子2</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjTEOgkAQRWksjHqH8QAUoBAsDcFYWdGTdZmFSdbdzc6YeBZPqxAOQPWL_9_72-TbjhExZYnK9WB8fCkh78BbGrx7a4teqEeeKiA30pOE3AD4CRGZ56mBJi9hMrCOFGbeKC1_IodJq0KwpBexAVl3uU82RlnGw5K75Hhr2vqeYvAdclAaHUpXP7KsKs7lJS-upzWbH8maVEA</recordid><startdate>20240827</startdate><enddate>20240827</enddate><creator>WANG LEI</creator><creator>WANG DEZHI</creator><creator>LEI WENZHUO</creator><scope>EVB</scope></search><sort><creationdate>20240827</creationdate><title>Three-strand formation oligonucleotides for inhibiting expression of E26 transcription factor 2 and application of three-strand formation oligonucleotides</title><author>WANG LEI ; WANG DEZHI ; LEI WENZHUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118546925A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG LEI</creatorcontrib><creatorcontrib>WANG DEZHI</creatorcontrib><creatorcontrib>LEI WENZHUO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG LEI</au><au>WANG DEZHI</au><au>LEI WENZHUO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Three-strand formation oligonucleotides for inhibiting expression of E26 transcription factor 2 and application of three-strand formation oligonucleotides</title><date>2024-08-27</date><risdate>2024</risdate><abstract>The invention relates to the technical field of biological medicine, in particular to three-strand forming oligonucleotides for inhibiting E26 transcription factor 2 gene expression and application of the three-strand forming oligonucleotides, and the three-strand forming oligonucleotides and a promoter core region of an E26 transcription factor 2 gene can form an oligonucleotide sequence of three-strand DNA (Deoxyribose Nucleic Acid). A polyacrylamide gel electrophoresis experiment, an in-vitro transcription inhibition experiment and a cell proliferation inhibition experiment prove that the three-strand-forming oligonucleotide can form a stable three-strand DNA structure with a promoter core region, the transcriptional level of an E26 transcription factor 2 is inhibited, and the drug resistance of breast cancer cells to adriamycin is reduced. Meanwhile, the invention can be used for preparing drugs for treating breast cancer drug resistance.
本发明涉及生物医药技术领域，尤其涉及一类抑制E26转录因子2基因表达的三链形成寡核苷酸及其应用，该三链形成寡核苷酸能与E26转录因子2</abstract><oa>free_for_read</oa></addata></record> |
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| language | chi ; eng |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Three-strand formation oligonucleotides for inhibiting expression of E26 transcription factor 2 and application of three-strand formation oligonucleotides |
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