Synthesis method of vibeglone

The invention relates to the technical field of medicine synthesis, in particular to a synthesis method of vibeglone, which comprises the following steps: by taking a compound 6 as an initial raw material, reacting the initial raw material with a silane hydroxyl protection reagent under inert gas protection and alkaline conditions, and carrying out selective hydroxyl protection to obtain a compound 5; under the protection of inert gas, the compound 5 is subjected to a ring closing reaction under the alkaline condition, and a compound 4 is obtained; under the catalyst/hydrogen condition, the compound 4 is subjected to a reduction reaction to generate a compound 3; and then carrying out condensation reaction on the compound 3 and a compound 2, and carrying out deprotection under an acidic condition to obtain a compound 1 which is vibeglone. The synthesis method can improve the selectivity of reaction sites, has few by-products, simple reaction operation, convenient and efficient post-treatment and high yield, c