Preparation method and application of fatty diacid fragment

The invention belongs to the technical field of biological medicine and chemical synthesis, and particularly relates to a preparation method and application of a fatty diacid fragment. According to the preparation method of the fatty diacid fragment, long-chain fatty diacid of mono-tert-butyl is sequentially condensed with 1-glutamic acid tert-butyl ester, 2-(2-(2-amino ethyoxyl) ethyoxyl) acetic acid, 2-(2-(2-amino ethyoxyl) ethyoxyl) acetic acid and Fmoc-lysine to prepare the fatty diacid fragment. The purity of the fatty diacid fragment synthesized by the method is more than 99.0%, and the method is simple in steps, mild in conditions, easy to operate and amplify and suitable for industrial production. 本发明属于生物医药及化学合成技术领域，具体涉及一种脂肪二酸片段的制备方法及应用。本发明所述脂肪二酸片段的制备方法，通过单叔丁基的长链脂肪二酸依次与1-谷氨酸叔丁酯、2-(2-(2-氨基乙氧基)乙氧基)乙酸、2-(2-(2-氨基乙氧基)乙氧基)乙酸、Fmoc-赖氨酸进行缩合制备。本发明方法合成的脂肪二酸片段的纯度在99.0％以上，且步骤简洁、条件温和、容易操作及放大，适合工业化生产。