CD28 shedding blocker

A single domain antibody (sdAb) that blocks CD28 cleavage is provided. Also provided are dimeric agents comprising at least two membrane CD28 binding agents, methods of using the sdAb and/or dimeric agents, and pharmaceutical compositions and kits comprising the sdAb and/or dimeric agents. 提供阻断CD28剪...

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Bibliographische Detailangaben
Hauptverfasser:	MANDEL ITZHAK, BEN-MOSHE TAMIR, LEKOVITZ, ALEXANDER, SHULMAN, AVIDOR, FRIEDMANN-DROR, ANNA, HAKEEM MOHANNAD, SAPIR YUVAL, GARBE THOMAS, CHERZELSBURG, LUDWIG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A single domain antibody (sdAb) that blocks CD28 cleavage is provided. Also provided are dimeric agents comprising at least two membrane CD28 binding agents, methods of using the sdAb and/or dimeric agents, and pharmaceutical compositions and kits comprising the sdAb and/or dimeric agents. 提供阻断CD28剪切的单结构域抗体(sdAb)。还提供包括至少两个膜CD28结合剂的二聚体试剂、使用所述sdAb和/或二聚体试剂的方法以及包括所述sdAb和/或二聚体试剂的药物组合物和试剂盒。