Synthetic method of pyrrolo [3, 2-d] pyrimidine-4-ketone derivative

The invention relates to a synthetic method of a pyrrolo [3, 2-d] pyrimidine-4-ketone derivative, which comprises the following steps: under the action of a metal catalyst and alkali, reacting a compound I with a compound II in a solvent to obtain the pyrrolo [3, 2-d] pyrimidine-4-ketone derivative, the reaction formula is as follows. Compared with the existing synthesis method, the method has the following advantages: (1) the method has good functional group compatibility, and the substrate application range is wide; (2) the reaction conditions are mild, the operation is simple and convenient, the synthesis process is simple, the synthesis efficiency is high, and the yield is higher; (3) the raw materials are cheap and easy to obtain, the used catalyst is a cheap and easy-to-obtain metal catalyst, preferably cheap and easy-to-obtain cuprous iodide, the dosage is small, and the catalytic efficiency is high. Therefore, the invention provides an efficient and simple method for constructing the [3, 2-d] pyrimidi