Composite scaffold for bone tissue engineering and preparation method thereof

The invention relates to a biological material and a 3D printing technology, in particular to a composite scaffold for bone tissue engineering and a preparation method of the composite scaffold. The material is mainly prepared from polylactic acid and strontium ion doped mineralized collagen according to a weight part ratio of (8-12): (85-95). And the mineralized collagen is of a periodic arrangement structure which is formed by assembling minerals and collagen molecules in a controlled manner. The strontium ion-doped mineralized collagen composite material is prepared from the mineralized collagen and the strontium ion-doped mineralized collagen, so that the strontium ion-doped mineralized collagen composite material has ideal mechanical properties and also can provide good osteogenic activity to regulate cell response and promote bone tissue repair. 本发明涉及生物材料及3D打印技术，特别是涉及一种用于骨组织工程的复合支架及其制备方法。其主要由聚乳酸、锶离子掺杂的矿化胶原按以下重量份比制成：8~12∶85~95。矿化胶原是矿物与胶原分子受控组装成周期排列结构。本发明由于通过矿化胶原和锶离子掺杂的矿化胶原制成，其具有理想的力学性能，而且还应提供良好的成骨活性来调节细胞