Application of melastoma dodecandrum lour and aqueous extract and active component thereof in preparation of medicine for preventing and treating osteoporosis

The invention discloses application of melastoma dodecandrum lour and an aqueous extract and active ingredients thereof in preparation of medicines for preventing and treating osteoporosis. It is found for the first time that for osteoblasts induced by AGEs, H2O2 and TNF-alpha, the melastoma dodecandrum can remarkably promote cell proliferation, improve intracellular ALP activity, enable bone formation related protein expression to be up-regulated, enable RAGE and TNFR1 expression to be down-regulated and inhibit oxidative stress of the cells, it is indicated that the melastoma dodecandrum has a protection effect on the osteoblasts, the osteoblast activity is improved, new bone formation is promoted, and the effect of preventing and treating the osteoblasts is achieved. Finally, the purpose of preventing and treating osteoporosis is achieved. 本发明公开了地稔及其水提物和活性成分在制备骨质疏松防治药物中的应用。本发明首次发现，对于AGEs、H2O2和TNF-α诱导的成骨细胞，地稔能够显著促进细胞增殖、提高胞内ALP活性、使骨形成相关蛋白表达上调、使RAGE和TNFR1表达下调、抑制细胞发生氧化应激，表明地稔对成骨细胞具有保护作用，有助于提高成骨细胞活性，促进新骨形成，最终达到