Method for increasing yield of extracellular vesicles secreted by mesenchymal stem cells and application

The invention discloses a method for increasing the yield of extracellular vesicles secreted by mesenchymal stem cells and application, and relates to the technical field of biological materials and engineered exosomes. Radio signals generated by piezoelectric biological materials are used for stimulating cells, the yield of the extracellular vesicles secreted by the mesenchymal stem cells is increased, and the yield of the extracellular vesicles secreted by the mesenchymal stem cells is increased. The method has the advantages of simple operation, no exogenous gene transfer, no other additives such as small molecule drugs, nanoparticles and the like, no potential risks such as virus transfection vectors, cytotoxicity, carcinogenesis and the like, solves the problems that the extracellular vesicles EVs extracted by the traditional method are low in yield, high in cost and difficult to meet the production of biological preparation drugs, and has important social and economic benefits. 本发明公开了一种提高间充质干细胞分泌细胞外囊泡产量