Arcanobacterium pyogenes vaccine preparation as well as preparation method and application thereof

The invention relates to the technical field of vaccines, in particular to an arcanobacterium pyogenes vaccine preparation as well as a preparation method and application thereof. The arcanobacterium pyogenes vaccine preparation is prepared from the following raw materials: arcanobacterium pyogenes with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.28995 and an adjuvant, and the adjuvant comprises at least one of ISA 15, ISA 61, ISA 201 and aluminum hydroxide. According to the technical scheme, the arcanobacterium pyogenes are obtained by sampling from suspected arcanobacterium pyogenes lethal sheep and carrying out isolated culture, the arcanobacterium pyogenes contain more than 9 virulence genes, and animal experiments show that the arcanobacterium pyogenes have high virulence and are suitable for preparing arcanobacterium pyogenes vaccines. On the basis of the new discovery, an adjuvant is used for preparing an arcanobacterium pyogenes vaccine. The vaccine ob