Antibody libraries comprising common light chain, methods of making and uses thereof

The present invention relates to antibody libraries comprising a common light chain having heavy chain diversity, and methods of making the antibody libraries. The invention also relates to an application of the antibody library having heavy chain diversity and containing common light chains, wherei...

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Bibliographische Detailangaben
Hauptverfasser:	XU PEIFANG, YAN XINTIAN, LU YANQING, XU CAIYUN, LANG GUOJUN, XUE CHAORAN, LIU CHANJUAN, HAN YANGYANG, FANG XIAOPENG, SHANG RUISHA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to antibody libraries comprising a common light chain having heavy chain diversity, and methods of making the antibody libraries. The invention also relates to an application of the antibody library having heavy chain diversity and containing common light chains, wherein the antibody library is used for preparing a bispecific antibody having common light chains; and the prepared bispecific antibody containing the common light chain. 本发明涉及具有重链多样性的包含共同轻链的抗体库，以及制备所述抗体库的方法。本发明还涉及所述具有重链多样性的包含共同轻链的抗体库的用途，用于制备具有共同轻链的双特异性抗体；以及所制备的包含共同轻链的双特异性抗体。