Application of small molecule compound in preparation of antiviral drugs

The invention discloses application of a small molecule compound with a structure shown as a formula (I) in preparation of antiviral drugs, and belongs to the field of biological medicines. Researches find that the half effective concentrations (EC50) of the compound to PRRSV and ASFV are 0.34 M and...

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Hauptverfasser:	LI WENTAO, TAO YANFEI, ZHENG YOULE, WANG XU, CHANG MENGYU, SONG YANBIN, HUANG LINGLI, PENG DAPENG, XIE CHANGQING, LIU ZHENLI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses application of a small molecule compound with a structure shown as a formula (I) in preparation of antiviral drugs, and belongs to the field of biological medicines. Researches find that the half effective concentrations (EC50) of the compound to PRRSV and ASFV are 0.34 M and lt respectively; according to the present invention, the FIPV can be significantly inhibited under the condition of 0.1 M and C14 under the condition of 30 M, and the compound does not have the significant cytotoxic effect, has good drug-likeness, and has the potential of clinical treatment drug development. # imgabs0 # is represented by formula (I). 本发明公开了结构如下式（Ⅰ）所示的小分子化合物在制备抗病毒药物中的用途，属于生物医药领域。研究发现该化合物对于PRRSV和ASFV的半数有效浓度（EC50）分别为0.34µM和