Crosslinked glutathione response polymer vesicle as well as preparation method and application thereof

The invention belongs to the field of biological materials, and particularly relates to a cross-linked glutathione response polymer vesicle as well as a preparation method and application thereof. The preparation method of the vesicle comprises the following steps: 1) preparing a monomer 4-(((4-nitrophenyl) carbamoyl) oxy) benzyl methacrylate MA-NPA; (2) polymerizing the MA-NPA obtained in the step (1), 4-cyano valeric acid dithiobenzoate and oligomeric ethylene glycol to obtain POEG-PNPA (Polyethylene Glycol-Polyethylene Glycol); 3), the polymer POEG-PNPA and the entrapment medicine are self-assembled to form the cross-linked glutathione response polymer vesicles. According to the technical scheme, the cross-linked glutathione response polymer is obtained in a chemical cross-linking mode, the stability of the vesicles in a blood circulation system can be greatly promoted, and premature release of the medicine is avoided. 本发明属于生物材料领域，具体涉及一种交联的谷胱甘肽响应聚合物囊泡及其制备方法和应用。囊泡制备方法包括下述步骤：1)制备单体4-（（（4-硝基苯基）氨基甲酰基）氧基）甲基丙烯酸苄