Sea cucumber oligopeptide with sleep improving activity as well as preparation method and application of sea cucumber oligopeptide

The invention belongs to the technical field of bioactive peptides, and particularly relates to sea cucumber oligopeptide with sleep improving activity and a preparation method and application thereof. The sea cucumber oligopeptide helpful for improving sleep provided by the invention contains sea cucumber oligopeptide SCP1 and sea cucumber oligopeptide SCP2; the former amino acid is composed of the following four amino acids: tryptophan-histidine-proline-phenylalanine, and the molecular weight is 585.27 Da; the latter is composed of the following four amino acids: alanine-arginine-tryptophan-phenylalanine, and the molecular weight of the latter is 578.30 Da. The sea cucumber oligopeptide has a good sleep improving effect, and SCP1 and SCP2 have a synergistic effect in the aspect of prolonging sleep duration. 本发明属于生物活性肽技术领域，尤其涉及一种具有改善睡眠活性的海参低聚肽及其制备方法和应用。本发明提供的有助于改善睡眠的海参低聚肽含有海参低聚肽SCP1和海参低聚肽SCP2；前者由以下四种氨基酸组成：色氨酸-组氨酸-脯氨酸-苯丙氨酸，分子量为585.27Da；后者由以下四种氨基酸组成：丙氨酸-精氨酸-色氨酸-苯丙氨酸，分子量为578.30Da。该海参低聚肽具有良好的改善睡眠作用，且SCP1和SCP2在延长