Alltrenogest nano pre-concentrated solution as well as preparation method and application thereof

The invention discloses an altrenogest nano pre-concentrated solution as well as a preparation method and application thereof. The nano pre-concentrated solution is prepared from the following raw materials in percentage by mass: 0.5-2.5% of altrenogest, 0.5-2.5% of sodium alginate, 0.5-2.5% of sodium alginate and the balance of water. 15 to 29 percent of ethyl oleate; 45 to 65% of polyoxyethylene sorbitan monooleate; 15 to 30% of ethyl carbitol; and 1-5% of ethanol. The altrenogest nano pre-concentrated solution disclosed by the invention is convenient to use and can be randomly mixed and dissolved with water, so that the defect that a traditional altrenogest oil solution is immiscible with water is overcome; meanwhile, absorption of altrenogest through lymphatic circulation can be promoted, the bioavailability is improved, the bioavailability of oral absorption of the hydrated nano pre-concentrated solution is 497% of that of an altrenogest oil solution, and therefore the clinical dosage of altrenogest or t