Mycobacterium tuberculosis drug resistance related gene mutation site for albendamide and application thereof

The invention provides a gene mutation site related to drug resistance of mycobacterium tuberculosis to albendamide and application of the gene mutation site. Whether the 568th site of an ino1 gene has base A mutation into G or not, whether the 1171th site of a guaB2 gene has base G mutation into A or not and whether the 2290th site of an Rv1248c gene has base G mutation into A or not are detected, and drug resistance of mycobacterium tuberculosis to albendamide is judged; the method can be used for rapidly detecting the drug resistance of the mycobacterium tuberculosis to the albendamide. The mutation site newly found in the invention not only can improve the detection rate of the drug resistance of the albendamide, but also can provide a potential target spot for treating the drug resistance of the albendamide. 本发明提供一种结核分枝杆菌对丙硫异烟胺耐药相关基因突变位点及其应用，本申请检测ino1基因的第568位是否发生碱基A突变为G，guaB2基因的第1171位是否发生碱基G突变为A和Rv1248c基因的第2290位是否发生碱基G突变为A，判断结核分枝杆菌对丙硫异烟胺耐药，可用于结核分枝杆菌对丙硫异烟胺耐药性的快速检测。本申请新发现的突变位点不仅能提高丙硫异烟胺耐药检出率，还可为治疗丙硫异烟胺耐药提供