Method for preparing silitinib intermediate through nickel catalytic reduction coupling

The invention discloses a method for preparing a silitinib intermediate through nickel catalytic reduction coupling, which comprises the following steps: by taking (R)-3-aminobutanol as a starting raw material, carrying out reduction coupling on (R)-3-aminobutanol and a compound V under the action of halogenation, upper protection and a nickel catalyst to obtain a compound VI. The preparation method disclosed by the invention is novel, simple in synthetic process route, cheap and easily available in raw material and catalyst, high in preparation efficiency and suitable for large-scale industrial production. # imgabs0 # 本发明公开了一种镍催化还原偶联制备赛利替尼中间体的方法，该方法包括以(R)-3-氨基丁醇为起始原料，进行卤代，上保护，镍催化剂作用下与化合物Ⅴ进行还原偶联，得到化合物Ⅵ。本发明的制备方法新颖，合成工艺路线简单，原料及催化剂廉价易得，制备效率高，适于大规模工业化生产。#imgabs0#