Composition for targeted combination with LDLR and application thereof

The invention discloses a composition combined with LDLR in a targeted mode and application of the composition. The composition comprises nano-liposome and plasma protein. The composition provided by the invention has a strong interaction relationship with the LDLR receptor, and the binding rate of the composition and cells expressing the LDLR receptor can reach 90% or more, which indicates that the composition has high targeting to the cells expressing the LDLR receptor, such as parenchymal hepatic cells. The strong combination effect helps the composition to be rapidly and effectively combined with cells expressing LDLR receptors after the composition is loaded with the nucleic acid drugs, and the accurate targeting effect and delivery of the nucleic acid drugs are achieved. 本发明公开了一种靶向结合LDLR的组合物及其应用，所述组合物包含纳米脂质体和血浆蛋白。本发明提供的组合物与LDLR受体具有强相互作用关系，所述组合物与表达LDLR受体的细胞结合率可达90%以上，表明组合物具有对表达LDLR受体的细胞的高靶向性，所述表达LDLR受体的细胞例如为肝实质细胞。这种强结合效果有助于所述组合物装载核酸药物后快速有效地与表达LDLR受体的细胞相结合，实现精准的靶向作用和核酸药物的递送。