Chromosome outer circular DNA (deoxyribonucleic acid) related to gestational diabetes mellitus and application thereof
The invention relates to the technical field of biomarkers, and particularly discloses chromosome outer circular DNA (eccDNA) related to gestational diabetes mellitus and application thereof.The eccDNA PRDM16circle can serve as a biomarker to predict the risk that a pregnant woman suffers from GDM i...
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| creator | WANG JIN HAO DONGDONG NIE WENYING HOU FEI JIN HUA GAO FENGCHUN LI WUSHAN |
| description | The invention relates to the technical field of biomarkers, and particularly discloses chromosome outer circular DNA (eccDNA) related to gestational diabetes mellitus and application thereof.The eccDNA PRDM16circle can serve as a biomarker to predict the risk that a pregnant woman suffers from GDM in the later stage in the early pregnancy stage, and the biomarker eccDNA PRDM16circle has the advantages that the risk of the pregnant woman suffering from GDM in the later stage in the aspects of stability, sensitivity and specificity is obviously lowered, and the risk of the pregnant woman suffering from GDM in the later stage in the early pregnancy stage is lowered. The method has the great advantages that the area under an ROC curve is 0.941, the sensitivity is 98.6%, the specificity is 71.4%, and 95% CI is equal to 0.907-0.975, so that the plasma PRDM16circle has a certain auxiliary diagnosis value for a GDM patient.
本申请涉及生物标志物技术领域，具体公开了一种与妊娠期糖尿病相关的染色体外环状DNA(eccDNA)及应用，本申请的eccDNA PRDM16circle可以作为生物标志物在孕早期预测妊娠妇 |
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本申请涉及生物标志物技术领域，具体公开了一种与妊娠期糖尿病相关的染色体外环状DNA(eccDNA)及应用，本申请的eccDNA PRDM16circle可以作为生物标志物在孕早期预测妊娠妇</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240806&DB=EPODOC&CC=CN&NR=118441035A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240806&DB=EPODOC&CC=CN&NR=118441035A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WANG JIN</creatorcontrib><creatorcontrib>HAO DONGDONG</creatorcontrib><creatorcontrib>NIE WENYING</creatorcontrib><creatorcontrib>HOU FEI</creatorcontrib><creatorcontrib>JIN HUA</creatorcontrib><creatorcontrib>GAO FENGCHUN</creatorcontrib><creatorcontrib>LI WUSHAN</creatorcontrib><title>Chromosome outer circular DNA (deoxyribonucleic acid) related to gestational diabetes mellitus and application thereof</title><description>The invention relates to the technical field of biomarkers, and particularly discloses chromosome outer circular DNA (eccDNA) related to gestational diabetes mellitus and application thereof.The eccDNA PRDM16circle can serve as a biomarker to predict the risk that a pregnant woman suffers from GDM in the later stage in the early pregnancy stage, and the biomarker eccDNA PRDM16circle has the advantages that the risk of the pregnant woman suffering from GDM in the later stage in the aspects of stability, sensitivity and specificity is obviously lowered, and the risk of the pregnant woman suffering from GDM in the later stage in the early pregnancy stage is lowered. The method has the great advantages that the area under an ROC curve is 0.941, the sensitivity is 98.6%, the specificity is 71.4%, and 95% CI is equal to 0.907-0.975, so that the plasma PRDM16circle has a certain auxiliary diagnosis value for a GDM patient.
本申请涉及生物标志物技术领域，具体公开了一种与妊娠期糖尿病相关的染色体外环状DNA(eccDNA)及应用，本申请的eccDNA PRDM16circle可以作为生物标志物在孕早期预测妊娠妇</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQBuAuDqK-w7npIFiq4Fqq4tTJvVyTvzaQ9kpyEX17QXwAp2_55tmz6oMMEmUASVIEMi6Y5DnQuS5pYyGvd3CtjMl4OENsnN1SgGeFJRV6ICqrk5E9WcctFJEGeO80ReLREk-Td-Z7SHsESLfMZh37iNXPRba-Xu7VbYdJGsSJDUZoU9V5fjoc8n1xLIt_zgcyJUXD</recordid><startdate>20240806</startdate><enddate>20240806</enddate><creator>WANG JIN</creator><creator>HAO DONGDONG</creator><creator>NIE WENYING</creator><creator>HOU FEI</creator><creator>JIN HUA</creator><creator>GAO FENGCHUN</creator><creator>LI WUSHAN</creator><scope>EVB</scope></search><sort><creationdate>20240806</creationdate><title>Chromosome outer circular DNA (deoxyribonucleic acid) related to gestational diabetes mellitus and application thereof</title><author>WANG JIN ; HAO DONGDONG ; NIE WENYING ; HOU FEI ; JIN HUA ; GAO FENGCHUN ; LI WUSHAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN118441035A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>WANG JIN</creatorcontrib><creatorcontrib>HAO DONGDONG</creatorcontrib><creatorcontrib>NIE WENYING</creatorcontrib><creatorcontrib>HOU FEI</creatorcontrib><creatorcontrib>JIN HUA</creatorcontrib><creatorcontrib>GAO FENGCHUN</creatorcontrib><creatorcontrib>LI WUSHAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WANG JIN</au><au>HAO DONGDONG</au><au>NIE WENYING</au><au>HOU FEI</au><au>JIN HUA</au><au>GAO FENGCHUN</au><au>LI WUSHAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Chromosome outer circular DNA (deoxyribonucleic acid) related to gestational diabetes mellitus and application thereof</title><date>2024-08-06</date><risdate>2024</risdate><abstract>The invention relates to the technical field of biomarkers, and particularly discloses chromosome outer circular DNA (eccDNA) related to gestational diabetes mellitus and application thereof.The eccDNA PRDM16circle can serve as a biomarker to predict the risk that a pregnant woman suffers from GDM in the later stage in the early pregnancy stage, and the biomarker eccDNA PRDM16circle has the advantages that the risk of the pregnant woman suffering from GDM in the later stage in the aspects of stability, sensitivity and specificity is obviously lowered, and the risk of the pregnant woman suffering from GDM in the later stage in the early pregnancy stage is lowered. The method has the great advantages that the area under an ROC curve is 0.941, the sensitivity is 98.6%, the specificity is 71.4%, and 95% CI is equal to 0.907-0.975, so that the plasma PRDM16circle has a certain auxiliary diagnosis value for a GDM patient.
本申请涉及生物标志物技术领域，具体公开了一种与妊娠期糖尿病相关的染色体外环状DNA(eccDNA)及应用，本申请的eccDNA PRDM16circle可以作为生物标志物在孕早期预测妊娠妇</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Chromosome outer circular DNA (deoxyribonucleic acid) related to gestational diabetes mellitus and application thereof |
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