Chromosome outer circular DNA (deoxyribonucleic acid) related to gestational diabetes mellitus and application thereof

The invention relates to the technical field of biomarkers, and particularly discloses chromosome outer circular DNA (eccDNA) related to gestational diabetes mellitus and application thereof.The eccDNA PRDM16circle can serve as a biomarker to predict the risk that a pregnant woman suffers from GDM in the later stage in the early pregnancy stage, and the biomarker eccDNA PRDM16circle has the advantages that the risk of the pregnant woman suffering from GDM in the later stage in the aspects of stability, sensitivity and specificity is obviously lowered, and the risk of the pregnant woman suffering from GDM in the later stage in the early pregnancy stage is lowered. The method has the great advantages that the area under an ROC curve is 0.941, the sensitivity is 98.6%, the specificity is 71.4%, and 95% CI is equal to 0.907-0.975, so that the plasma PRDM16circle has a certain auxiliary diagnosis value for a GDM patient. 本申请涉及生物标志物技术领域，具体公开了一种与妊娠期糖尿病相关的染色体外环状DNA(eccDNA)及应用，本申请的eccDNA PRDM16circle可以作为生物标志物在孕早期预测妊娠妇