Modified polyvinyl alcohol microsphere and preparation method thereof

The invention relates to the technical field of medical materials, and particularly provides a modified polyvinyl alcohol microsphere and a preparation method thereof, and the preparation method comprises the following steps: an oil phase preparation step, a water phase preparation step, a microsphere preparation step and a modification treatment step. The modified polyvinyl alcohol microsphere has a better structure formed by chemical crosslinking, still has higher compression elasticity on the premise of higher strength, and meets clinical use requirements; and the process is simple, the operation conditions are easy to control, and the raw material polyvinyl alcohol is non-toxic, excellent in flexibility and good in biocompatibility. 本发明涉及医用材料技术领域，具体提供了一种改性聚乙烯醇微球及其制备方法，所述制备方法包括如下步骤：油相制备步骤、水相制备步骤、微球制备步骤以及改性处理步骤。该改性聚乙烯醇微球具有较好的化学交联形成的结构，在具有较高强度的前提下，仍具有较高的压缩弹性，满足临床使用需求；且工艺简单，操作条件易控制，原料聚乙烯醇具有无毒性、优异的柔韧性以及良好的生物相容性。