Humanized rabies virus nano-antibody, recombinant nano-antibody protein and application of humanized rabies virus nano-antibody and recombinant nano-antibody protein in preparation of rabies prevention and treatment products

The invention relates to the technical field of biological medicines, in particular to a humanized rabies virus nano-antibody, a recombinant nano-antibody protein and application of the humanized rabies virus nano-antibody and the recombinant nano-antibody protein in preparation of products for preventing and treating rabies. A humanized rabies virus nano antibody which is relatively strong in binding force with rabies virus glycoprotein and has blood-brain barrier penetrating capacity is obtained through screening, then EGFP and a blood-brain barrier penetrating peptide T7 or PepH3 are respectively connected to the C terminal of the humanized rabies virus nano antibody, an antibody fusion protein gene is cloned to a prokaryotic expression vector pMal-p5x, expression and purification are performed through a prokaryotic expression engineering bacterium Shuffle T7, and the recombinant rabies virus nano antibody is obtained. The recombinant nano antibody protein can enter a central nervous system from veins to c